Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers.

@article{Lammers2009SimultaneousDO,
  title={Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers.},
  author={Twan Lammers and Vladim{\'i}r {\vS}ubr and Karel Ulbrich and P. Peschke and Peter E Huber and Wim E Hennink and Gert Storm},
  journal={Biomaterials},
  year={2009},
  volume={30 20},
  pages={3466-75}
}
Copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized polymeric drug carriers that have been broadly implemented in the delivery of anticancer therapeutics. To demonstrate that polymers, as liposomes, can be used for simultaneously delivering multiple chemotherapeutic agents to tumors in vivo, we have synthesized and evaluated an HPMA-based polymer-drug conjugate carrying 6.4wt% of gemcitabine, 5.7wt% of doxorubicin and 1.0mol% of tyrosinamide (to allow… CONTINUE READING
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