Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure.

@article{Pfluger2008SimultaneousDO,
  title={Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure.},
  author={Paul T Pfluger and Henriette Kirchner and Susanne G{\"u}nnel and Brigitte Schrott and Diego P{\'e}rez-Tilve and Sheng Yung Fu and Stephen C. Benoit and Tam{\'a}s Horv{\'a}th and Hans-Georg Joost and Katherine E Wortley and M W Sleeman and Matthias H Tsch{\"o}p},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2008},
  volume={294 3},
  pages={G610-8}
}
Administration of chemically synthesized ghrelin (Ghr) peptide has been shown to increase food intake and body adiposity in most species. However, the biological role of endogenous Ghr in the molecular control of energy metabolism is far less understood. Mice deficient for either Ghr or its receptor (the growth hormone secretagogue receptor, GHS-R1a) seem to exhibit enhanced protection against high-fat diet-induced obesity but do not show a substantial metabolic phenotype on a standard diet… CONTINUE READING

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