Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes

@article{Bushel2006SimultaneousCO,
  title={Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes},
  author={Pierre R. Bushel and Russell D. Wolfinger and Greg Gibson},
  journal={BMC Systems Biology},
  year={2006},
  volume={1},
  pages={15 - 15}
}
Commonly employed clustering methods for analysis of gene expression data do not directly incorporate phenotypic data about the samples. Furthermore, clustering of samples with known phenotypes is typically performed in an informal fashion. The inability of clustering algorithms to incorporate biological data in the grouping process can limit proper interpretation of the data and its underlying biology. We present a more formal approach, the modk-prototypes algorithm, for clustering biological… CONTINUE READING
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