Simultaneous chiral analysis of methamphetamine and related compounds by capillary electrophoresis.

  title={Simultaneous chiral analysis of methamphetamine and related compounds by capillary electrophoresis.},
  author={S. Chinaka and S. Tanaka and N. Takayama and K. Komai and T. Ohshima and K. Ueda},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  volume={749 1},
  • S. Chinaka, S. Tanaka, +3 authors K. Ueda
  • Published 2000
  • Chemistry, Medicine
  • Journal of chromatography. B, Biomedical sciences and applications
A capillary electrophoretic method for the simultaneous chiral analysis of nine cationic drugs (18 enantiomers) has been developed. These drugs are methamphetamine (MA), amphetamine, dimethylamphetamine, ephedrine (EP), norephedrine, methylephedrine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxy-N-ethylamphetamine. The chiral selector, which was added to the electrolyte, was a mixture of beta-cyclodextrin and heptakis(2,6-di-O-methyl)-beta-cyclodextrin… Expand
Simultaneous chiral analysis of methamphetamine and related compounds by capillary electrophoresis/mass spectrometry using anionic cyclodextrin.
A capillary electrophoresis/mass spectrometry method for the simultaneous chiral analysis of enantiomers of methamphetamine (MA), amphetamine (AP), dimethylamphetamine (DMA), ephedrine (EP),Expand
Profiling of levoamphetamine and related substances in dexamphetamine sulfate by capillary electrophoresis.
Comparison with polarimetric measurements indicated that dexamphetamine with an enantiomeric excess as low as 80% still passes the pharmacopeial test of specific rotation while an amount of 0.06% of levoamphetamine can be detected by capillary electrophoresis. Expand
The application of capillary electrophoresis for enantiomeric separation of N,N-dimethylamphetamine and its related analogs: intelligence study on N,N-dimethylamphetamine samples in crystalline and tablet forms.
A new capillary zone electrophoresis method has been applied to the measurement of the enantiomeric purities of the seized DMA samples and could provide important clues about the possible synthetic pathways of these samples. Expand
Simultaneous chiral analysis of amphetamine-type stimulants and ephedrine by capillary electrophoresis coupled to time-of-flight mass spectrometry.
Capillary electrophoresis coupled to time-of-flight mass spectrometry was used for simultaneous chiral separation of amphetamine-type stimulants and ephedrine in Shanghai for inferring the synthetic pathways of drugs. Expand
Enantiomeric separation of amphetamine and related compounds by liquid chromatography using precolumn derivatization witho-phthaldialdehyde
SummaryThe utility of the derivatization reagento-phthaldialdehyde (OPA) in combination with the chiral thiol N-acetyl-L-cysteine (NAC) for the enantioselective analysis of primary amphetamines andExpand
Simultaneous identification of the enantiomers and diastereomers of N,O-di-trifluoroacetylated ephedrine and norephedrine in blood plasma using chiral capillary gas chromatography-mass spectrometry with selected ion monitoring.
This chiral capillary SIM GC-MS method was sufficiently effective in the analysis of plasma from users of over-the-counter cold medicines and was also fully applicable to the plasma analysis of guinea pigs following their treatment with racemic EP. Expand
Separation of the enantiomers of primary and secondary amphetamines by liquid chromatography after derivatization with (−)-1-(9-fluorenyl)ethyl chloroformate
SummaryThe chiral reagent (−)-1-(9-fluorenyl)ethyl chloroformate (FLEC) has been evaluated for the enantioselective analysis of amphetamines by liquid chromatography. For separation of the FLECExpand
Enantiomeric separation of some common controlled stimulants by capillary electrophoresis with contactless conductivity detection
The developed CE‐C4D method was successfully applied to urine samples of athletes for the identification of enantiomers of the detected stimulants. Expand
CE assay for simultaneous determination of charged and neutral impurities in dexamphetamine sulfate using a dual CD system
A CE assay for the simultaneous determination of charged and uncharged potential impurities of dexamphetamine sulfate including the stereoisomer levoamphetamine was developed and validated and phenylacetone and phenolacetone oxime could be observed at the LOD, indicating the synthetic origin of the investigated samples. Expand
Strategies for the enantiomeric determination of amphetamine and related compounds by liquid chromatography.
This paper summarizes recent research on the stereospecific analysis of amphetamine, its analogs and metabolites, by liquid chromatography and suggests a promising alternative to beta-cyclodextrins as chiral selectors, both immobilized on the stationary phase and added to the mobile phase. Expand


Chiral resolution of cationic drugs of forensic interest by capillary electrophoresis with mixtures of neutral and anionic cyclodextrins.
The use of mixtures of the neutral and the anionic CD (beta-CD sulfobutyl ether IV) was found suitable for the analysis of illicit amphetamine, methamphetamine, methcathinone, and propoxyphene. Expand
Stereoselective screening for and confirmation of urinary enantiomers of amphetamine, methamphetamine, designer drugs, methadone and selected metabolites by capillary electrophoresis
The suitability of the described chiral electrokinetic capillary method for drug screening and confirmation is demonstrated via analysis of unhydrolyzed quality control urines containing a variety of drugs of abuse. Expand
Simultaneous chiral separation of 3,4‐methylenedioxymethamphetamine (MDMA), 3‐4‐methylenedioxyamphetamine (MDA), 3,4‐methylenedioxyethylamphetamine (MDE), ephedrine, amphetamine and methamphetamine by capillary electrophoresis in uncoated and coated capillaries with native β‐cyclodextrin as the chir
The importance of the chiral analysis of amphetamine‐related substances in both clandestine preparations and biological samples is widely recognized. For this purpose, capillary electrophoresis wasExpand
Chiral separation of amphetamines by high-performance capillary electrophoresis
The chiral separation of amphetamines is of great importance in clinical and forensic analysis, because it is well known that enantiomers do not have identical pharmacological activity; for example,Expand
Capillary electrophoretic enantioseparation of selegiline, methamphetamine and ephedrine using a neutral beta-cyclodextrin epichlorhydrin polymer.
This paper describes the development of a capillary zone electrophoretic method for chiral separation of three basic compounds of the selegiline synthetic pathway: ephedrine, methamphetamine and se LEGiline using a neutral beta-cyclodextrin epichlorhydrin polymer. Expand
Stereoselective analyses of selegiline metabolites: possible urinary markers for selegiline therapy.
This chiral analysis is the most useful technique to avoid the misinterpretation in the discrimination between clinical selegiline therapy and illicit MA use. Expand
Effects of various anionic chiral selectors on the capillary electrophoresis separation of chiral phenethylamines and achiral neutral impurities present in illicit methamphetamine
In this study, various anionic chiral selectors were investigated for the capillary electrophoresis (CE) separation of six chiral phenethylamines and three achiral neutral impurities which areExpand
The metabolism of dimethylamphetamine in rat and man.
  • T. Inoue, S. Suzuki
  • Biology, Medicine
  • Xenobiotica; the fate of foreign compounds in biological systems
  • 1987
Urinary metabolites of dimethyl methamphetamine after oral administration to rat and healthy human volunteers have been studied and the major metabolite was dimethylamphetamine N-oxide in both cases, and methamphetamine and amphetamine were also excreted as minor metabolites. Expand