Simultaneous blockade of dopamine and noradrenaline reuptake promotes disadvantageous decision making in a rat gambling task

@article{Baarendse2012SimultaneousBO,
  title={Simultaneous blockade of dopamine and noradrenaline reuptake promotes disadvantageous decision making in a rat gambling task},
  author={Petra J. J. Baarendse and Catharine A. Winstanley and Louk J. M. J. Vanderschuren},
  journal={Psychopharmacology},
  year={2012},
  volume={225},
  pages={719-731}
}
The inability to make profitable long-term decisions has been implicated in several psychiatric disorders. There is emerging evidence to support a role for dopamine (DA) in decision making, but our understanding of the role of noradrenaline (NA) and serotonin (5-HT) in decision making, and of possible interactions between the three monoamines, is limited. Moreover, impulsivity has been associated with aberrant decision making, but the underlying mechanisms are incompletely understood. The… CONTINUE READING
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