Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective cyclooxygenase 2 inhibitors and nonselective nonsteroidal antiinflammatory drugs: an instrumental variable analysis.

@article{Schneeweiss2006SimultaneousAO,
  title={Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective cyclooxygenase 2 inhibitors and nonselective nonsteroidal antiinflammatory drugs: an instrumental variable analysis.},
  author={Sebastian Schneeweiss and Daniel H. Solomon and Philip Sung-En Wang and Jeremy A. Rassen and M. Alan Brookhart},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 11},
  pages={3390-8}
}
OBJECTIVE To simultaneously assess the short-term reduction in risk of gastrointestinal (GI) complications and increase in risk of acute myocardial infarction (MI) by celecoxib compared with rofecoxib and several nonselective nonsteroidal antiinflammatory drugs (NSAIDs) using instrumental variable analysis. METHODS A population of 49,711 Medicare beneficiaries ages 65 years and older who initiated nonselective NSAID or selective cyclooxygenase 2 inhibitor therapy between January 1, 1999, and… CONTINUE READING

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