Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia.

@article{Maas2008SimultaneousAO,
  title={Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia.},
  author={Renke Maas and Edzard Schwedhelm and L. Alex Kahl and Huige Li and Ralf Benndorf and Nicole L{\"u}neburg and Ulrich Foerstermann and Rainer H. Boeger},
  journal={Clinical chemistry},
  year={2008},
  volume={54 2},
  pages={292-300}
}
BACKGROUND Endothelial function is impaired in hypercholesterolemia and atherosclerosis. Based on mostly indirect evidence, this impairment is attributed to reduced synthesis or impaired biological activity of endothelium-derived nitric oxide (NO). It was the aim of this study to directly estimate and compare whole-body NO production in normo- and hypercholesterolemia by applying a nonradioactive stable isotope dilution technique in vivo. METHODS We enrolled 12 normocholesterolemic and 24… CONTINUE READING

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