Simultaneous assessment of CD4 and MHC-I downregulation by Nef primary isolates in the context of infection.

@article{Ali2009SimultaneousAO,
  title={Simultaneous assessment of CD4 and MHC-I downregulation by Nef primary isolates in the context of infection.},
  author={Ayub Ali and Susan Realegeno and Otto O Yang and Martha J Lewis},
  journal={Journal of virological methods},
  year={2009},
  volume={161 2},
  pages={
          297-304
        }
}
  • Ayub Ali, Susan Realegeno, +1 author Martha J Lewis
  • Published in
    Journal of virological…
    2009
  • Biology, Medicine
  • The HIV-1 Nef protein plays a key role in pathogenesis, as demonstrated by strong selective pressure to maintain its open reading frame, and disease attenuation when it is deleted. Among myriad cellular effects attributed to Nef, downregulation of cell surface CD4 and major histocompatibility complex class I (MHC-I) proteins are the best documented. However, few data regarding primary isolate Nef functions are available, and most studies have been performed using transient transfections to… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Topics from this paper.

    Citations

    Publications citing this paper.
    SHOWING 1-9 OF 9 CITATIONS

    HIV-1 Nef Sequence and Functional Compartmentalization in the Gut Is Not Due to Differential Cytotoxic T Lymphocyte Selective Pressure

    VIEW 4 EXCERPTS
    CITES RESULTS, METHODS & BACKGROUND

    Functional analysis of HIV type 1 Nef gene variants from adolescent and adult survivors of perinatal infection.

    VIEW 4 EXCERPTS
    CITES BACKGROUND & METHODS

    Dynamic range of Nef functions in chronic HIV-1 infection.

    VIEW 2 EXCERPTS
    CITES BACKGROUND