Simultaneous analysis of six novel hallucinogenic (tetrahydrobenzodifuranyl)aminoalkanes (FLYs) and (benzodifuranyl)aminoalkanes (DragonFLYs) by GC-MS, LC-MS, and LC-MS-MS

  title={Simultaneous analysis of six novel hallucinogenic (tetrahydrobenzodifuranyl)aminoalkanes (FLYs) and (benzodifuranyl)aminoalkanes (DragonFLYs) by GC-MS, LC-MS, and LC-MS-MS},
  author={Kei Zaitsu and Munehiro Katagi and Hiroe T. Kamata and Keiko Nakanishi and Noriaki Shima and Tooru Kamata and Hiroshi Nishioka and Akihiro Miki and Michiaki Tatsuno and Hitoshi Tsuchihashi},
  journal={Forensic Toxicology},
Six novel hallucinogens classed as (tetrahydrobenzodifuranyl) aminoalkanes or (benzodifuranyl)aminoalkanes, which are known by the common names of “FLY” and “DragonFLY,” respectively, were synthesized. These compounds were simultaneously analyzed by gas chromatography (GC)-mass spectrometry (MS), liquid chromatography (LC)-MS, and LC-MS-MS. GCMS analysis of their free bases was not satisfactory for both mass spectral and chromatographic measurements, and thus trifluoroacetyl (TFA… 
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Recently abused β-keto derivatives of 3,4-methylenedioxyphenylalkylamines: a review of their metabolisms and toxicological analysis

Abstractβ-Keto derivatives of 3,4-methylenedioxyphenylalkylamines (bk-MDPAs), especially 2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one (methylone),

Analysis of new designer drugs and common drugs of abuse in urine by a combined targeted and untargeted LC-HR-QTOFMS approach

The development of a liquid chromatography high-resolution mass spectrometry quadrupole-time-of-flight method for the analysis of new stimulant designer drugs and common drugs of abuse in urine is reported, providing a very useful tool for the combined targeted and untargeted analysis of drugs ofabuse in biological matrices such as urine.

Colorimetric detection and chromatographic analyses of designer drugs in biological materials: a comprehensive review

A number of analogues of phenethylamine and tryptamine, which are prepared by modification of the chemical structures, are being developed for circulation on the black market. Often called “designer

An introduction to drug testing: the expanding role of mass spectrometry.

This chapter introduces the reader to the application of MS to TDM and toxicology, the steps that should be considered during implementation, and the processes thatshould be implemented to assure continued quality.



Discrimination and identification of regioisomeric β-keto analogues of 3,4-methylenedioxyamphetamines by gas chromatography-mass spectrometry

Very recently, β-keto derivatives of 3,4-methylenedioxyamphetamines (MDAs) have appeared on the illicit drug market. In the present study, we synthesized three isomers of β-keto derivatives of MDAs,

Simultaneous analysis of six phenethylamine-type designer drugs by TLC, LC-MS, and GC-MS

Extensive data are presented for simultaneous analysis of six phenethylamine-type designer drugs. The drugs are 2,5-dimethoxyphenethylamine (2C-H), 2,5-dimethoxyamphetamine (2,5-DMA),

Discrimination and identification of the six aromatic positional isomers of trimethoxyamphetamine (TMA) by gas chromatography-mass spectrometry (GC-MS).

This GC-MS technique in combination with TFA derivatization is a powerful method to discriminate these isomers, especially useful to distinguish the currently controlled 3,4,5-trimethoxyamphetmine (TMA-1) and 2,3,4- Trifluoroacetyl (TFA-2) from other uncontrolled TMAs.

Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives.

The loss of activity in the 3,4,5-trioxygenated mescaline analogues may suggest that the 3 and 5 methoxy groups must remain conformationally mobile to enable receptor activation.

Simultaneous Analysis of New Designer Drug, Methylone, and Its Metabolites in Urine by Gas Chromatography-Mass Spectrometry and Liquid Chromatography- Electrospray Ionization Mass Spectrometry

In order to prove the intake of a newly encountered designer drug, Methylone, a sensitive and useful method, which allows us to simultaneously detect Methylone and its metabolites in human urine, has

Conjugates of p-hydroxymethamphetamine and 4-hydroxy-3-methoxymethamphetamine in blood obtained from methamphetamine and 3,4-methylenedioxymethamphetamine users: analysis by LC-MS-MS

The present study clearly showed the presence of conjugated forms of p-OHMA and HMMA in human blood; the levels of sulfate conjugates were much higher than those of glucuronide conjugATES.

2,5-ジメトキシ-4-アルキルチオフェネチルアミン(2C-T 類)の分析

2,5-Dimethoxy-4-alkylthiophenethylamines (2C-T analogs), new psychedelic phenethylamines, were synthesized and analytical procedures for these compounds were investigated. Thin-layer chromatography

Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups.

The results suggest that the dihydrofuran rings in these new analogues effectively model the active binding conformations of the methoxy groups of the parent compounds 1 and 2.

Metabolism of the recently encountered designer drug, methylone, in humans and rats

The results demonstrate that the analysis of HMMC will be indispensable for proof of the use of methylone in forensic urinalysis.