Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

@article{Delan1978SimultaneousAO,
  title={Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.},
  author={A Del{\'e}an and Paul J. Munson and David Rodbard},
  journal={The American journal of physiology},
  year={1978},
  volume={235 2},
  pages={
          E97-102
        }
}
Physiological and pharmacological studies of hormones, drugs, and neurotransmitters often generate families of sigmoidal dose-response curves. Optimally efficient data analysis should involve simultaneous description of all curves, rather than fitting each one individually. We have developed a general computerized method to describe the dose-response curves in terms of basal and maximal responses, ED50, and curve shape or steepness. This facile method permits rigorous statistical analysis… CONTINUE READING
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