Simultaneous analyses of the neurochemical and behavioral effects of the norepinephrine reuptake inhibitor reboxetine in a rat model of antidepressant action

@article{Page2002SimultaneousAO,
  title={Simultaneous analyses of the neurochemical and behavioral effects of the norepinephrine reuptake inhibitor reboxetine in a rat model of antidepressant action},
  author={Michelle E. Page and Kevin Scott Brown and Irwin Lucki},
  journal={Psychopharmacology},
  year={2002},
  volume={165},
  pages={194-201}
}
Abstract Rationale. The forced swimming test (FST) is a rodent behavioral assay widely used to predict clinical efficacy of putative antidepressants. Few studies have examined the effects of the FST on neurotransmitter levels and how antidepressant drug treatment may alter neurotransmitter levels and behavior simultaneously during the performance of a stressful task. Objectives. The present study examined the role of norepinephrine in mediating active behaviors in the FST after treatment with… CONTINUE READING
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