Simultaneous acute Marchiafava–Bignami disease and central pontine myelinolysis

  title={Simultaneous acute Marchiafava–Bignami disease and central pontine myelinolysis},
  author={Chun-Yi Tsai and Po-Kai Huang and Poyin Huang},
Rationale: Marchiafava–Bignami disease (MBD) is a rare disease characterized by demyelination of the corpus callosum. It is most commonly seen in patients with chronic alcoholism. The clinical diagnosis of MBD can be difficult due to its nonspecific manifestation. Central pontine myelinolysis (CPM) occurs mostly as a complication of severe and prolonged hyponatremia, especially when corrected too rapidly. However, CPM can be associated with chronic alcoholism and its clinical presentation can… 
3 Citations
Marchiafava‑Bignami Disease: The Importance of Early Diagnosis and Treatment by a Multidisciplinary Team
The case of a 34‑year‑old male with a 10‑year history of alcohol dependence who was admitted to the hospital, after having been found lying on the floor of his house, malnourished and with pressure ulcers on his chest and knees, is reported.
Simultaneous acute Marchiafava-Bignami disease and posterior reversible encephalopathy syndrome: a case almost misdiagnosed.
A 49-year-old male alcoholic with both MBD and PRES who had a good prognosis after correct diagnosis and timely treatment is reported.
Marchiafava-Bignami disease: Report of three cases.
Three patients who had history of chronic alcoholism, different clinical presentation and MRI findings consistent with the diagnosis of Marchiafava-Bignami disease are reported.


Diagnosis and management of Marchiafava–Bignami disease: a review of CT/MRI confirmed cases
As thiamine deficiency is frequently associated with alcoholism, malnutrition and prolonged vomiting; it is recommended that prompt treatment of MBD with parenteralThiamine in such subjects should be followed by repeated neuropsychological and MRI examinations.
Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes
  • R. Martin
  • Medicine, Psychology
    Journal of Neurology, Neurosurgery & Psychiatry
  • 2004
The clinical, pathological, and aetiological features of the disease, the dilemma facing clinicians treating patients with severe hyponatraemia, and treatment opportunities are discussed.
Association of central pontine myelinolysis and Marchiafava‐Bignami disease
Combined pathologic features of central pontine myelinolysis and Marchiafava-Bignami disease occurred in a 53-year-old man with chronic alcoholism, suggesting a common pathogenetic mechanism.
Teaching NeuroImages: Radiologic findings in Marchiafava-Bignami disease
A 42-year-old man without known history of alcoholism presented comatose. CT and MRI (figure) demonstrated characteristic imaging features of Marchiafava-Bignami disease1 without signs of Wernicke
Neuroimaging findings in alcohol-related encephalopathies.
Alcohol-related encephalopathies can be life-threatening conditions but can be prevented or treated, if recognized.
Molecular and neurologic responses to chronic alcohol use.