Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice.

@article{Kobayashi2004SimultaneousAO,
  title={Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice.},
  author={Minoru Kobayashi and Ciro Iaccarino and Adolfo Saiardi and Val{\'e}rie Heidt and Yuri Bozzi and Roberto Picetti and Carmine Vitale and Heiner Westphal and John L Drago and Emiliana Borrelli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 31},
  pages={11465-70}
}
Dopamine (DA) controls a wide variety of physiological functions in the central nervous system as well as in the neuroendocrine and gastrointestinal systems. DA signaling is mediated by five cloned receptors named D1-D5. Knockout mouse models for the five receptors have been generated, and, albeit impaired for some important DA-mediated functions, they are viable and can reproduce. D1 and D2 receptors are the most abundant and widely expressed DA receptors. Cooperative/synergistic effects… CONTINUE READING

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