Simultaneous Spectrophotometric Estimation of Atorvastatin and Fenofibrate in Bulk Drug and Dosage Form by Using Simultaneous Equation Method

Abstract

Atorvastatin– fenofibrate combination used in the treatment of hypercholesterolemia and hypertriglyceridemia. Various methods for analysis of the same are available but are time consuming and expensive. Here we have developed a new, precise and simple UV spectrophotometric method for estimation of atorvastatin – fenofibrate from tablet formulation. The drug obeyed the Beer’s law and showed good correlation. Absorption maxima of atorvastatin and fenofibrate in methanol were found to be at 245nm and 285nm respectively. Beer’s law was obeyed in concentration range 8-24 μg/ml for atovastatin and 2-16 μg/ml for fenofibrate. The results of analysis were validated by recovery studies. The recovery was more than 98%. The method was found to be simple, accurate, precise, economical and robust.

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Cite this paper

@inproceedings{Dhabale2003SimultaneousSE, title={Simultaneous Spectrophotometric Estimation of Atorvastatin and Fenofibrate in Bulk Drug and Dosage Form by Using Simultaneous Equation Method}, author={Pandurang Dhabale and D. S. Gharge}, year={2003} }