Corpus ID: 88523435

Simultaneous Selection of Multiple Important Single Nucleotide Polymorphisms in Familial Genome Wide Association Studies Data

  title={Simultaneous Selection of Multiple Important Single Nucleotide Polymorphisms in Familial Genome Wide Association Studies Data},
  author={S. Majumdar and S. Basu and M. McGue and Snigdhansu Chatterjee},
  journal={arXiv: Applications},
We propose a resampling-based fast variable selection technique for selecting important Single Nucleotide Polymorphisms (SNP) in multi-marker mixed effect models used in twin studies. Due to computational complexity, current practice includes testing the effect of one SNP at a time, commonly termed as `single SNP association analysis'. Joint modeling of genetic variants within a gene or pathway may have better power to detect the relevant genetic variants, hence we adapt our recently proposed… Expand


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