Simultaneous Recording of Cerebral Blood Oxygenation Changes during Human Brain Activation by Magnetic Resonance Imaging and Near-Infrared Spectroscopy

@article{Kleinschmidt1996SimultaneousRO,
  title={Simultaneous Recording of Cerebral Blood Oxygenation Changes during Human Brain Activation by Magnetic Resonance Imaging and Near-Infrared Spectroscopy},
  author={Andreas Kleinschmidt and Hellmuth Obrig and Martin Requardt and Klaus-Dietmar Merboldt and Ulrich Dirnagl and Arno Villringer and Jens Frahm},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  year={1996},
  volume={16},
  pages={817 - 826}
}
Changes in cerebral blood oxygenation due to functional activation of the primary sensorimotor cortex during a unilateral finger opposition task were simultaneously mapped by deoxyhemoglobin-sensitive magnetic resonance imaging (MRI) and monitored by near-infrared spectroscopy (NIRS). Activation foci along the contralateral central sulcus displayed task-associated increases in MRI signal intensity, indicating a concomitant decrease of the focal concentration of deoxyhemoglobin. This… 
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TLDR
This work proceeded from a rather global, cognitive stimulus to experimental paradigms which entail a more localized cerebral activation and which have been examined by other functional techniques, and was interested in the time course of local oxygenation changes.
Simultaneous assessment of human brain functional hemodynamics by magnetic resonance and near-infrared imaging
Near-infrared spectroscopy is a relatively new imaging method, which can provide important information on concentrations of oxy-and deoxy-hemoglobin in cortical areas of the brain. We discuss the…
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To clarify the characteristics of the evoked cerebral blood oxygenation (CBO) changes occurring in stroke and brain tumors, near-infrared spectroscopy (NIRS) and BOLD-fMRI recording during functional brain activation in these patients are compared.
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The electrical stimulation of GPi and VIM caused various CBO changes in the frontal lobe, which were similar to those found during cognitive tasks and may be caused by complex neuronal circuits inThe frontal lobe which has many neuronal connections to other cortical areas or the basal ganglia.
A Quantitative Comparison of Simultaneous BOLD fMRI and NIRS Recordings during Functional Brain Activation
TLDR
Strong correlations were found between fMRI changes and all optical measures, with oxyhemoglobin providing the strongest correlation, and this finding held even when including scalp, skull, and inactive brain tissue in the average BOLD signal.
Simultaneous measurements of cerebral oxygenation changes during brain activation by near‐infrared spectroscopy and functional magnetic resonance imaging in healthy young and elderly subjects
TLDR
It is demonstrated that NIRS and fMRI similarly assess cortical oxygenation changes in young subjects and also in elderly subjects, and cortex oxygenation responses to brain activation alter with aging.
Simultaneous assessment of cerebral oxygenation and hemodynamics during a motor task. A combined near infrared and transcranial Doppler sonography study.
TLDR
This study proves the feasibility of a simultaneous assessment of microcirculatory hemodynamics and cerebral oxygenation at high temporal resolution and shows a pronounced initial over-shoot.
Brain Cortical Mapping by Simultaneous Recording of Functional Near Infrared Spectroscopy and Electroencephalograms from the Whole Brain During Right Median Nerve Stimulation
TLDR
The present results suggest that simultaneous NIRS and EEG recording is useful for correlating hemodynamic responses to neural activity and suggests that GLM analysis with onset delay could reveal the temporal ordering of neural activation in the hierarchical somatosensory pathway, consistent with the neurophysiological data.
Changes of cerebral blood oxygenation and optical pathlength during activation and deactivation in the prefrontal cortex measured by time-resolved near infrared spectroscopy.
Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging.
TLDR
A high temporal correlation between the BOLD signal (fMRI) and the deoxy-hemoglobin concentration (NIRS) in the subjects who exhibited low fluctuations in superficial head tissues is found.
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