Simultaneous Molecular and Hypoxia Imaging of Brain Tumors In Vivo Using Spectroscopic Photoacoustic Tomography

@article{Li2008SimultaneousMA,
  title={Simultaneous Molecular and Hypoxia Imaging of Brain Tumors In Vivo Using Spectroscopic Photoacoustic Tomography},
  author={Meng-Lin Li and Jung-Taek Oh and Xueyi Xie and Geng Ku and Wei Wang and Chun Xing Li and Gina Lungu and George Stoica and Lihong V. Wang},
  journal={Proceedings of the IEEE},
  year={2008},
  volume={96},
  pages={481-489}
}
Noninvasive molecular and functional imaging in vivo is promising for detecting and monitoring various physiological conditions in animals and ultimately humans. [...] Key Method SPAT successfully imaged with high resolution the distribution of a molecular contrast agent targeting integrin overexpressed in human U87 glioblastomas in nude mouse brains. Simultaneously, SPAT also imaged the hemoglobin oxygen saturation and the total hemoglobin concentration of the vasculature, which revealed hypoxia in tumor…Expand
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