Simultaneous Manipulation of Multiple Brain Targets by Green Tea Catechins: A Potential Neuroprotective Strategy for Alzheimer and Parkinson Diseases

  title={Simultaneous Manipulation of Multiple Brain Targets by Green Tea Catechins: A Potential Neuroprotective Strategy for Alzheimer and Parkinson Diseases},
  author={Silvia A. Mandel and Tamar Amit and Orly Weinreb and Lydia Reznichenko and Moussa B. H. Youdim},
  journal={CNS Neuroscience \& Therapeutics},
Current therapeutic approaches for Alzheimer and Parkinson disease (AD and PD, respectively) are merely symptomatic, intended for the treatment of symptoms, but offer only partial benefit, without any disease‐modifying activity. Novel promising strategies suggest the use of antiinflammatory drugs, antioxidants, iron‐complexing molecules, neurotrophic factor delivery, inhibitors of the amyloid precursor protein (APP)‐processing secretases, gamma and beta (that generate the amyloid‐beta peptides… 

Molecular mechanisms of the neuroprotective/neurorescue action of multi-target green tea polyphenols.

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Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders

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Due to its simpler structure and more efficient blood–brain barrier penetration properties, epicatechin might be the best therapeutic candidate for neurodegenerative diseases including HIV-associated neurocognitive disorders where oxidative stress is an important pathophysiological mechanism.

The Herbal Preparation Padma® 28 Protects Against Neurotoxicity in PC12 Cells

The study investigated the protective effect of Padma 28 and of certain polyphenols on the neurotoxicity of PC12 cells induced by the neurotoxins known to be involved in AD, Parkinson's disease, amyotrophic‐lateral‐sclerosis (ALS) and Huntington's disease (HD), and found that the decrease in cell viability induced by each of the toxins was significantly attenuated byPadma 28 treatment.



Multifunctional Activities of Green Tea Catechins in Neuroprotection

This review will focus on the multifunctional properties of green tea and its major component (–)-epigallocatechin-3-gallate (EGCG) and their ability to induce neuroprotection and neurorescue in vitro and in vivo and their transitional metal chelating property and inhibition of oxidative stress.

Potent anti‐amyloidogenic and fibril‐destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

Although the mechanisms by which these polyphenols inhibit fAβ formation from Aβ, and destabilize pre‐formed fA βin vitro are still unclear, polyphenol could be a key molecule for the development of preventives and therapeutics for AD.

Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice

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Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases

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Neuroprotection and neurorescue against Aβ toxicity and PKC‐dependent release of non‐amyloidogenic soluble precursor protein by green tea polyphenol (‐)‐epigallocatechin‐3‐gallate

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Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models.

Curcumin might exert a net protective effect against Abeta toxicity or might suppress inflammatory damage by preventing metal induction of NF-kappaB.