Simultaneous LFA-1 and CD40 ligand antagonism prevents airway remodeling in orthotopic airway transplantation: implications for the role of respiratory epithelium as a modulator of fibrosis.

@article{Murakawa2005SimultaneousLA,
  title={Simultaneous LFA-1 and CD40 ligand antagonism prevents airway remodeling in orthotopic airway transplantation: implications for the role of respiratory epithelium as a modulator of fibrosis.},
  author={Tomohiro Murakawa and Michelle M. Kerklo and Maigualida Zamora and Yi Wei and Ronald G Gill and Peter M Henson and Frederick L. Grover and Mark R Nicolls},
  journal={Journal of immunology},
  year={2005},
  volume={174 7},
  pages={
          3869-79
        }
}
Airway remodeling is a prominent feature of certain immune-mediated lung diseases such as asthma and chronic lung transplant rejection. Under conditions of airway inflammation, the respiratory epithelium may serve an important role in this remodeling process. Given the proposed role of respiratory epithelium in nonspecific injury models, we investigated the respiratory epithelium in an immune-specific orthotopic airway transplant model. MHC-mismatched tracheal transplants in mice were used to… CONTINUE READING
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