Simultaneous β1 integrin-EGFR targeting and radiosensitization of human head and neck cancer.

@article{Eke2015SimultaneousI,
  title={Simultaneous β1 integrin-EGFR targeting and radiosensitization of human head and neck cancer.},
  author={I. P. Eke and Katja Zscheppang and Ellen Dickreuter and Linda Hickmann and Ercole Mazzeo and Kristian Unger and Mechthild Krause and Nils Cordes},
  journal={Journal of the National Cancer Institute},
  year={2015},
  volume={107 2}
}
BACKGROUND Signaling from integrins and receptor tyrosine kinases (RTKs) contributes substantially to therapy resistance of malignant tumors. We investigated simultaneous β1 integrin-epidermal growth factor receptor (EGFR) targeting plus radiotherapy in human head and neck squamous cell carcinomas (HNSCCs). METHODS Ten HNSCC cell lines were grown in three-dimensional laminin-rich extracellular matrix cell cultures and two of them as tumor xenografts in nude mice (n = 12-16 per group… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 27 CITATIONS

Efficacy of Beta1 Integrin and EGFR Targeting in Sphere-Forming Human Head and Neck Cancer Cells

  • Journal of Cancer
  • 2016
VIEW 8 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Integr(at)in(g) EGFR therapy in HNSCC.

  • Annals of translational medicine
  • 2015
VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED