Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b.

  title={Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b.},
  author={Jonathan M. Shipley and David J Waxman},
  journal={Toxicology and applied pharmacology},
  volume={199 3},
The transcription factors peroxisome proliferator-activated receptor (PPAR) and signal transducer and activator of transcription 5 (STAT5) activate genes involved in fatty acid metabolism (PPARalpha) and adipogenesis (PPARgamma) and mediate hormonal responses important for body growth, liver gene expression, and mammary gland development (STAT5a and STAT5b). These seemingly disparate pathways are subject to mutually inhibitory crosstalk, with growth hormone (GH)-activated STAT5 able to inhibit… CONTINUE READING


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