Simulations of membrane-bound diglycosylated human prion protein reveal potential protective mechanisms against misfolding.

Abstract

Prion diseases are associated with the misfolding of the prion protein (PrP) from its normal cellular form (PrPC ) to its infectious scrapie form (PrPSc ). Post-translational modifications in PrP in vivo can play an important role in modulating the process of misfolding. To gain more insight into the effects of post-translational modifications in PrP… (More)
DOI: 10.1111/jnc.14044

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