Simulations of macromolecules in protective and denaturing osmolytes: properties of mixed solvent systems and their effects on water and protein structure and dynamics.

Abstract

Rarely is any solution simply solute and water. In vivo, solutes, such as proteins and nucleic acids, swim in a sea of water, salts, ions, small molecules, and lipids, not to mention other macromolecules. In vitro, virtually all solutions contain a mixture of aqueous solvents, or "cosolvents" [i.e., solvent(s) in addition to water], that can alter the… (More)

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@article{Beck2007SimulationsOM, title={Simulations of macromolecules in protective and denaturing osmolytes: properties of mixed solvent systems and their effects on water and protein structure and dynamics.}, author={David A. C. Beck and Brian J. Bennion and Darwin O V Alonso and Valerie Daggett}, journal={Methods in enzymology}, year={2007}, volume={428}, pages={373-96} }