Simulations of Enhancer Evolution Provide Mechanistic Insights into Gene Regulation

@inproceedings{Duque2014SimulationsOE,
  title={Simulations of Enhancer Evolution Provide Mechanistic Insights into Gene Regulation},
  author={Thyago S. P. C. Duque and Md. Abul Hassan Samee and Majid Kazemian and Hannah N. Pham and Michael H. Brodsky and Saurabh Sinha},
  booktitle={Molecular biology and evolution},
  year={2014}
}
There is growing interest in models of regulatory sequence evolution. However, existing models specifically designed for regulatory sequences consider the independent evolution of individual transcription factor (TF)-binding sites, ignoring that the function and evolution of a binding site depends on its context, typically the cis-regulatory module (CRM) in which the site is located. Moreover, existing models do not account for the gene-specific roles of TF-binding sites, primarily because… CONTINUE READING
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