Simulation study on effects of signaling network structure on the developmental increase in complexity.

@article{Kernen2004SimulationSO,
  title={Simulation study on effects of signaling network structure on the developmental increase in complexity.},
  author={Soile V. E. Ker{\"a}nen},
  journal={Journal of theoretical biology},
  year={2004},
  volume={231 1},
  pages={3-21}
}
The developmental increase in structural complexity in multicellular lifeforms depends on local, often non-periodic differences in gene expression. These, in turn, depend on a network of gene-gene interactions coded within the organismal genome. To see what architectural features of a network (size, connectivity, etc.) affect the likelihood of patterns with multiple cell types (i.e. patterns where cells express > or = 3 different combinations of genes), developmental pattern formation was… CONTINUE READING