Simulation study of the reliability and robustness of the statistical methods for detecting positive selection at single amino acid sites.

  • Yoshiyuki Suzuki, Masatoshi Nei
  • Published 2002 in Molecular biology and evolution
Inferring positive selection at single amino acid sites is of biological and medical importance. Parsimony-based and likelihood-based methods have been developed for this purpose, but the reliabilities of these methods are not well understood. Because the evolutionary models assumed in these methods are only rough approximations to reality, it is desirable… (More)