Simulation study of the effects of multiple treatments in the mouse bone marrow micronucleus test.

@article{Hayashi1991SimulationSO,
  title={Simulation study of the effects of multiple treatments in the mouse bone marrow micronucleus test.},
  author={Masahiko Hayashi and Toshio Sofuni and Takeshi Morita},
  journal={Mutation research},
  year={1991},
  volume={252 3},
  pages={281-7}
}
The effect of multiple treatment with chemicals in the micronucleus test was evaluated by simulation involving an estimation of the additive accumulation of micronucleated polychromatic erythrocytes (MNPCEs) on the basis of time-response data available on single treatments with mitomycin C, 1-beta-D-arabinofuranosylcytosine, 6-mercaptopurine, and methotrexate. The frequency of MNPCEs calculated for different multiple treatment regimens by the model could predict the effects observed in real… CONTINUE READING
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