Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk.

@article{Ung2008SimulationOT,
  title={Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk.},
  author={Choong Yong Ung and Hu Li and Xiao Hua Ma and Jia Jia and Bao Wen Li and Boon Chuan Low and Yu Zong Chen},
  journal={FEBS letters},
  year={2008},
  volume={582 15},
  pages={2283-90}
}
Deregulations of EGFR endocytosis in EGFR-ERK signaling are known to cause cancers and developmental disorders. Mutations that impaired c-Cbl-EGFR association delay EGFR endocytosis and produce higher mitogenic signals in lung cancer. ROCK, an effector of small GTPase RhoA was shown to negatively regulate EGFR endocytosis via endophilin A1. A mathematical… CONTINUE READING