Simulation of high-frequency sinusoidal electrical block of mammalian myelinated axons

@article{Bhadra2006SimulationOH,
  title={Simulation of high-frequency sinusoidal electrical block of mammalian myelinated axons},
  author={Niloy Bhadra and Emily A. Lahowetz and Stephen T. Foldes and Kevin L. Kilgore},
  journal={Journal of Computational Neuroscience},
  year={2006},
  volume={22},
  pages={313-326}
}
High frequency alternating current (HFAC) sinusoidal waveforms can block conduction in mammalian peripheral nerves. A mammalian axon model was used to simulate the response of nerves to HFAC conduction block. Sinusoidal waveforms from 1  to 40 kHz were delivered to eight simulated axon diameters ranging from 7.3  to 16 μm. Conduction block was obtained between 3  to 40 kHz. The minimum peak to peak current at which block was obtained, defined as the block threshold, increased with increasing… CONTINUE READING

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