Simulation of gentamicin delivery for the local treatment of osteomyelitis.

  title={Simulation of gentamicin delivery for the local treatment of osteomyelitis.},
  author={Chian Guan Lee and Yin-Chih Fu and Chi-Hwa Wang},
  journal={Biotechnology and bioengineering},
  volume={91 5},
In order to understand the effect of antibiotics delivery to bone tissue, by biodegradable polymeric drug disc, for the treatment of osteomyelitis, a three-dimensional simulation model is developed. The simulation investigates the effect of pressure-induced convection on drug distribution, by taking into account the pressure gradient that exists between capillaries and interstitial space, and also as a result of the surgical opening. The clotting process at the surgical opening is incorporated… CONTINUE READING