Simulation of drug release from biodegradable polymeric microspheres with bulk and surface erosions.

@article{Zhang2003SimulationOD,
  title={Simulation of drug release from biodegradable polymeric microspheres with bulk and surface erosions.},
  author={Mingping Zhang and Zichao Yang and Li-Ling Chow and Chi-Hwa Wang},
  journal={Journal of pharmaceutical sciences},
  year={2003},
  volume={92 10},
  pages={2040-56}
}
New models are developed to account for the kinetics of drug release from porous, biodegradable polymeric microspheres under the schemes of bulk erosion and surface erosion of the polymer matrix, respectively. Three mechanisms of drug release, namely, drug diffusion, drug dissolution, and polymer erosion jointly govern the overall release process. For bulk erosion, the model incorporates an erosion term into the dissolution and diffusion equation and is solved numerically for various boundary… CONTINUE READING