Simulation and analysis of hepatic indicator dilution curves.

  title={Simulation and analysis of hepatic indicator dilution curves.},
  author={B. Luxon and E. L. Forker},
  journal={The American journal of physiology},
  volume={243 1},
The "multiple-indicator dilution method" of measuring hepatic transport kinetics is subjected to simulation analysis. The objective is to examine the errors that may arise from treating the nonexchanging vasculature as a simple delay and to study the information content of simulated venous outflow curves. We find that the method cannot be counted on to provide consistently reliable estimates of either the transport rate constants or the sinusoidal volume. Estimates of the rate constant for… Expand
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