Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure

@inproceedings{Trnor2012SimulationAM,
  title={Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure},
  author={Beatriz Tr{\'e}nor and Karen Cardona and Juan F. Gomez and Sridharan Rajamani and Jos{\'e} M. Ferrero and Luiz Belardinelli and Javier Saiz},
  booktitle={PloS one},
  year={2012}
}
Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na(+) current (I(NaL)) is relevant and is currently under investigation. In this study we examined the role of I(NaL) in the electrophysiological phenotype of ventricular myocytes, and its proarrhythmic effects in the failing heart. A model for cellular heart failure was proposed using a modified version… CONTINUE READING
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Undrovinas AI (2006) A multi-modal composition of the late Na+ current in human ventricular cardiomyocytes

  • VA Maltsev
  • Cardiovasc Res
  • 2006
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