Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.

@article{Kuzumoto2008SimulationAO,
  title={Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.},
  author={Masanori Kuzumoto and Ayako Takeuchi and Hiroyuki Nakai and Chiaki Oka and Akinori Noma and Satoshi Matsuoka},
  journal={Progress in biophysics and molecular biology},
  year={2008},
  volume={96 1-3},
  pages={
          171-86
        }
}
To quantitatively understand intracellular Na+ and Cl- homeostasis as well as roles of Na+/K+ pump and cystic fibrosis transmembrane conductance regulator Cl- channel (ICFTR) during the beta1-adrenergic stimulation in cardiac myocyte, we constructed a computer model of beta1-adrenergic signaling and implemented it into an excitation-contraction coupling model of the guinea-pig ventricular cell, which can reproduce membrane excitation, intracellular ion changes (Na+, K+, Ca2+ and Cl… CONTINUE READING

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