Simulation Methods for Optimal Experimental Design in Systems Biology

@article{Faller2003SimulationMF,
  title={Simulation Methods for Optimal Experimental Design in Systems Biology},
  author={Daniel Faller and Ursula Klingm{\"u}ller and Jens Timmer},
  journal={Simulation},
  year={2003},
  volume={79},
  pages={717-725}
}
To obtain a systems-level understanding of a biological system, the authors conducted quantitative dynamic experiments from which the system structure and the parameters have to be deduced. Since biological systems have to cope with different environmental conditions, certain properties are often robust with respect to variations in some of the parameters. Hence, it is important to use optimal experimental design considerations in advance of the experiments to improve the information content of… CONTINUE READING

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