Simulation-Based Validation of the p53 Transcriptional Activity with Hybrid Functional Petri Net.

@article{Doi2011SimulationBasedVO,
  title={Simulation-Based Validation of the p53 Transcriptional Activity with Hybrid Functional Petri Net.},
  author={Atsushi Doi and Masao Nagasaki and Hiroshi Matsuno and Satoru Miyano},
  journal={Studies in health technology and informatics},
  year={2011},
  volume={162},
  pages={
          130-42
        }
}
MDM2 and p19ARF are essential proteins in cancer pathways forming a complex with protein p53 to control the transcriptional activity of protein p53. It is confirmed that protein p53 loses its transcriptional activity by forming the functional dimer with protein MDM2. However, it is still unclear that protein p53 keeps its transcriptional activity when it forms the trimer with proteins MDM2 and p19ARF. We have observed mutual behaviors among genes p53, MDM2, p19ARF and their products on a… CONTINUE READING

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