Simulating psoriasis by altering transit amplifying cells

  title={Simulating psoriasis by altering transit amplifying cells},
  author={Niels Grabe and Karsten Neuber},
  volume={23 11},
Computational models of tissue homeostasis will facilitate a deeper understanding of many diseases. They link molecular networks, cellular differentiation and the spatial and temporal organization of tissues. Here we show an approach which is able to computationally turn a healthy in silico epidermis into one with four central properties of psoriatic epidermis. We achieve this by altering a single simulation parameter in the cellular differentiation program of the simulated epidermal… CONTINUE READING


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