Simulating neurocognitive aging: effects of a dopaminergic antagonist on brain activity during working memory.


BACKGROUND Previous correlational studies have indirectly linked dysfunctional dopaminergic neurotransmission to age-related cognitive deficits and associated reductions in task-induced functional brain activity. METHODS We used an experimental-pharmacological functional magnetic resonance imaging (fMRI) approach to more directly examine the role of… (More)
DOI: 10.1016/j.biopsych.2009.12.013


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