Simulating microinjection experiments in a novel model of the rat sleep-wake regulatory network.

@article{Behn2010SimulatingME,
  title={Simulating microinjection experiments in a novel model of the rat sleep-wake regulatory network.},
  author={Cecilia G Diniz Behn and Victoria K Booth},
  journal={Journal of neurophysiology},
  year={2010},
  volume={103 4},
  pages={1937-53}
}
This study presents a novel mathematical modeling framework that is uniquely suited to investigating the structure and dynamics of the sleep-wake regulatory network in the brain stem and hypothalamus. It is based on a population firing rate model formalism that is modified to explicitly include concentration levels of neurotransmitters released to postsynaptic populations. Using this framework, interactions among primary brain stem and hypothalamic neuronal nuclei involved in rat sleep-wake… CONTINUE READING