Simulating growth dynamics and radiation response of avascular tumour spheroids - model validation in the case of an EMT6/Ro multicellular spheroid

@article{Zacharaki2004SimulatingGD,
  title={Simulating growth dynamics and radiation response of avascular tumour spheroids - model validation in the case of an EMT6/Ro multicellular spheroid},
  author={Evangelia I. Zacharaki and Georgios S. Stamatakos and Konstantina S. Nikita and Nikolaos K. Uzunoglu},
  journal={Computer methods and programs in biomedicine},
  year={2004},
  volume={76 3},
  pages={193-206}
}
The goal of this paper is to provide both the basic scientist and the clinician with an advanced computational tool for performing in silico experiments aiming at supporting the process of biological optimisation of radiation therapy. Improved understanding and description of malignant tumour dynamics is an additional intermediate objective. To this end an advanced three-dimensional (3D) Monte-Carlo simulation model of both the avascular development of multicellular tumour spheroids and their… CONTINUE READING

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