Simulating Properties of In Vitro Epithelial Cell Morphogenesis

  title={Simulating Properties of In Vitro Epithelial Cell Morphogenesis },
  author={Mark R. Grant and Keith E. Mostov and Thea D. Tlsty and C. Anthony Hunt},
  journal={PLoS Computational Biology},
  pages={531 - 537}
How do individual epithelial cells (ECs) organize into multicellular structures? ECs are studied in vitro to help answer that question. Characteristic growth features include stable cyst formation in embedded culture, inverted cyst formation in suspension culture, and lumen formation in overlay culture. Formation of these characteristic structures is believed to be a consequence of an intrinsic program of differentiation and de-differentiation. To help discover how such a program may function… CONTINUE READING


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