Simulating Linkage Disequilibrium Structures in a Human Population for SNP Association Studies

@article{Yuan2011SimulatingLD,
  title={Simulating Linkage Disequilibrium Structures in a Human Population for SNP Association Studies},
  author={Xiguo Yuan and Junying Zhang and Yue Wang},
  journal={Biochemical Genetics},
  year={2011},
  volume={49},
  pages={395-409}
}
Existing simulation methods usually simulate linkage disequilibrium (LD) structures starting with an initial population that is randomly generated according to specified allele frequencies. These at random based methods might be unstable because the LD level of the initial population is generally extremely low. This study presents a new algorithm, SIMLD, to… CONTINUE READING