Simulated solar light-induced p53 mutagenesis in SKH-1 mouse skin: a dose-response assessment.

@article{Verkler2008SimulatedSL,
  title={Simulated solar light-induced p53 mutagenesis in SKH-1 mouse skin: a dose-response assessment.},
  author={Tracie L Verkler and Robert R. Delongchamp and Barbara J Miller and Peggy J Webb and Paul C. Howard and Barbara L. Parsons},
  journal={Molecular carcinogenesis},
  year={2008},
  volume={47 8},
  pages={599-607}
}
Sunlight and ultraviolet-induced mutation of the p53 gene is a frequent, possibly obligate step in skin cancer development, making quantitative measurement of p53 mutation an ideal biomarker for sunlight-induced skin carcinogenesis. To understand how the appearance of p53 mutation relates to skin tumor development, SKH-1 hairless mice were exposed 5 d per week to one of four different doses of simulated solar light (SSL; 0, 6.85, 13.70, 20.55 mJ x CIE/cm(2)) previously characterized for their… CONTINUE READING