Simulated microgravity enhances vasoconstrictor responsiveness of rat basilar artery.

@article{Zhang2001SimulatedME,
  title={Simulated microgravity enhances vasoconstrictor responsiveness of rat basilar artery.},
  author={Le-ning Zhang and Li-fan Zhang and Jin Ma},
  journal={Journal of applied physiology},
  year={2001},
  volume={90 6},
  pages={2296-305}
}
Recently, hypertrophy and increased myogenic tone of brain vessels have been observed in rats after simulated microgravity. It is expected that simulated microgravity may also induce hyperreactivity of brain vessels. To test this hypothesis, Sprague-Dawley rats were subjected to a 4-wk tail-suspended hindlimb unloading (TS) to simulate the cardiovascular deconditioning effect of microgravity. After 4 wk, the vasoreactivity of isolated basilar arterial rings from TS rats to both receptor- and… CONTINUE READING
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