Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling.

Abstract

We have previously shown that increased reactive oxygen species (ROS) generation occurs with ischemia in the oxygenated lung and have hypothesized that mechanotransduction is the initiating event. In the present study, we developed an in vitro model of oxygenated ischemia by interrupting medium flow to flow-adapted bovine pulmonary artery endothelial cells… (More)

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@article{Wei1999SimulatedII, title={Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling.}, author={Z. Wei and Kevin D. Costa and Abu-Bakr Al-Mehdi and Chandra Dodia and Vladimir R. Muzykantov and Aron B. Fisher}, journal={Circulation research}, year={1999}, volume={85 8}, pages={682-9} }