Simulated ischemia enhances L-type calcium current in pacemaker cells isolated from the rabbit sinoatrial node.

@article{Du2007SimulatedIE,
  title={Simulated ischemia enhances L-type calcium current in pacemaker cells isolated from the rabbit sinoatrial node.},
  author={Yi-mei Du and Richard D. Nathan},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 5},
  pages={H2986-94}
}
Ischemic-like conditions (a glucose-free, pH 6.6 Tyrode solution bubbled with 100% N(2)) enhance L-type Ca current (I(Ca,L)) in single pacemaker cells (PCs) isolated from the rabbit sinoatrial node (SAN). In contrast, studies of ventricular myocytes have shown that acidic extracellular pH, as employed in our "ischemic" Tyrode, reduces I(Ca,L). Therefore, our goal was to explain why I(Ca,L) is increased by "ischemia" in SAN PCs. The major findings were the following: 1) blockade of Ca-induced Ca… CONTINUE READING
9 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…