Simulated ischemia does not protect against efferent sympathetic denervation following acute myocardial infarction in canine hearts.

Abstract

INTRODUCTION Preconditioning the myocardium with brief episodes of ischemia preserves efferent autonomic responsiveness of noninfarcted myocardium apical to a site of acute transmural ischemia by mechanism(s) still unknown. We hypothesized that repeated brief exposure of the myocardium to a simulated ischemic milieu including hypoxia, high K+, low pH, and… (More)

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