Simulated ischaemia and reperfusion in isolated guinea pig ventricular myocytes.

@article{Cordeiro1994SimulatedIA,
  title={Simulated ischaemia and reperfusion in isolated guinea pig ventricular myocytes.},
  author={Jo{\"a}o Manuel Marques Cordeiro and Susan E Howlett and Gregory R. Ferrier},
  journal={Cardiovascular research},
  year={1994},
  volume={28 12},
  pages={1794-802}
}
OBJECTIVE The objectives were (1) to develop a cellular model of simulated ischaemia and reperfusion in isolated ventricular myocytes; (2) to determine effects of simulated ischaemia and reperfusion on calcium current (ICa), transient inward current (ITI) and contraction; and (3) to determine whether pharmacological agents which alter intracellular sodium and calcium loading affect signs of calcium overload in reperfusion in this model. METHODS Electrical activity was recorded with… CONTINUE READING

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