Simulated brain biopsy for diagnosing neurodegeneration using autopsy-confirmed cases

@article{Venneti2011SimulatedBB,
  title={Simulated brain biopsy for diagnosing neurodegeneration using autopsy-confirmed cases},
  author={Sriram Venneti and John L. Robinson and Subhojit Roy and Matthew T. White and Jennifer Baccon and Sharon X Xie and John Q. Trojanowski},
  journal={Acta Neuropathologica},
  year={2011},
  volume={122},
  pages={737-745}
}
Risks associated with brain biopsy limit availability of tissues and the role of brain biopsy in diagnosing neurodegeneration is unclear. We developed a simulated brain biopsy paradigm to comprehensively evaluate potential accuracy of detecting neurodegeneration in biopsies. Postmortem tissue from the frontal, temporal and parietal cortices and basal ganglia from 73 cases including Alzheimer’s disease (AD), Lewy body disease (LBD), frontotemporal lobar degeneration-TDP43 (FTLD-TDP), multiple… CONTINUE READING