Simulated Interactions between Endothelin Converting Enzyme and Aβ Peptide: Insights into Subsite Recognition and Cleavage Mechanism

@article{Barage2014SimulatedIB,
  title={Simulated Interactions between Endothelin Converting Enzyme and Aβ Peptide: Insights into Subsite Recognition and Cleavage Mechanism},
  author={Sagar H. Barage and Chidambar B. Jalkute and Maruti J. Dhanavade and Kailas D. Sonawane},
  journal={International Journal of Peptide Research and Therapeutics},
  year={2014},
  volume={20},
  pages={409-420}
}
Alzheimer’s disease (AD) is a most common form of dementia caused due to aggregation of amyloid beta (Aβ) peptides in brain. The AD brain exhibits extracellular deposition of Aβ-peptides which triggers neuronal death. Thus, degradation of Aβ peptides has evaluated a promising therapeutic target in AD. Human endothelin converting enzyme (hECE-1) has been implicated in Aβ-peptide degradation. In this study, we have performed molecular docking between three different conformations of Aβ peptides… CONTINUE READING